[WPS] 2024.02 W5

  1. Conditional transcriptome-wide association study for fine-mapping candidate causal genes | Nature Genetics
  2. Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy | Nature Genetics
  3. Adjusting for genetic confounders in transcriptome-wide association studies improves discovery of risk genes of complex traits | Nature Genetics
  4. Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer | Nature Genetics
  5. Accurate and sensitive mutational signature analysis with MuSiCal | Nature Genetics
  6. Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression | Nature Genetics
  7. Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease | Nature Genetics
  8. Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns | Nature Genetics
  9. Mechanisms of action and resistance in histone methylation-targeted therapy | Nature
  10. Genomic data in the All of Us Research Program | Nature
  11. Deep whole-genome analysis of 494 hepatocellular carcinomas | Nature
  12. Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory | Nature
  13. An immunogenetic basis for lung cancer risk | Science
  14. Lineage-specific intolerance to oncogenic drivers restricts histological transformation | Science
  15. Whole-brain spatial organization of hippocampal single-neuron projectomes | Science
  16. Changing fitness effects of mutations through long-term bacterial evolution | Science
  17. The transcription factor ZEB2 drives the formation of age-associated B cells | Science
  18. Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies | Science
  19. Machine learning interpretable models of cell mechanics from protein images: Cell
  20. Autism-related dietary preferences mediate autism-gut microbiome associations: Cell
  21. Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma: Cell
  22. Dissecting the spatiotemporal diversity of adult neural stem cells | Molecular Systems Biology (embopress.org)
  23. Deep learning for protein structure prediction and design—progress and applications | Molecular Systems Biology (embopress.org)
  24. Machine learning identifies key metabolic reactions in bacterial growth on different carbon sources | Molecular Systems Biology (embopress.org)
  25. Machine learning inference of continuous single-cell state transitions during myoblast differentiation and fusion | Molecular Systems Biology (embopress.org)
  26. Quality assessment of gene repertoire annotations with OMArk | Nature Biotechnology
  27. Simultaneous single-cell analysis of 5mC and 5hmC with SIMPLE-seq | Nature Biotechnology
  28. Mosaic integration and knowledge transfer of single-cell multimodal data with MIDAS | Nature Biotechnology
  29. Decoder-seq enhances mRNA capture efficiency in spatial RNA sequencing | Nature Biotechnology
  30. Disentanglement of single-cell data with biolord | Nature Biotechnology
  31. Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA | Nature Biotechnology
  32. Fast mass spectrometry search and clustering of untargeted metabolomics data | Nature Biotechnology
  33. Towards Generalist Biomedical AI | NEJM AI
  34. Adapted large language models can outperform medical experts in clinical text summarization | Nature Medicine
  35. Assessment of a Large Language Model’s Responses to Questions and Cases About Glaucoma and Retina Management | Glaucoma | JAMA Ophthalmology | JAMA Network

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