[카테고리:] Weekly Paper Selections – WPS

1. Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex | Nature Genetics 2. Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk | Nature Genetics 3. The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes | Nature…

1. Quantifying cell divisions along evolutionary lineages in cancer | Nature Genetics 2. Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation | Nature Genetics 3. Engineered heart muscle allografts for heart repair in primates and humans | Nature 4. Genomics yields biological and phenotypic insights into bipolar disorder | Nature…

1. The next generation of in situ multi-omics | Nature Methods 2. Multimodal cell mapping with optimal transport 3. 2025.01.27.25321204v1.full.pdf 4. 2025.01.27.635074.full.pdf

1. Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes | Nature Genetics 2. Transcript-specific enrichment enables profiling of rare cell states via single-cell RNA sequencing | Nature Genetics 3. Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition | Nature Genetics 4. Massively parallel characterization of…

1. Nucleosome fibre topology guides transcription factor binding to enhancers | Nature 2. Spatiotemporal modeling of molecular holograms: Cell 3. Decoding transcriptional identity in developing human sensory neurons and organoid modeling: Cell 4. State of the interactomes: an evaluation of molecular networks for generating biological insights | Molecular Systems Biology

1. Study design features increase replicability in brain-wide association studies – Nature … Optimizing study design is critical for increasing standardized effect sizes and replicability, and the features that increase replicability in cross-sectional and longitudinal brain-wide association studies are explored. 2. https://www.cell.com/cell/fulltext/S0092-8674(24)01272-8 3. https://www.cell.com/cell/fulltext/S0092-8674(24)01201-7 4. https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012490 Conditional probabilistic diffusion model driven synthetic radiogenomic applications in…

1. https://meetings.aps.org/Meeting/NEF24/Session/B03.2 2. https://www.science.org/doi/10.1126/science.adn9947 3. https://www.nature.com/articles/s41588-024-01961-x 4. https://www.nature.com/articles/s41588-024-01975-5 5. https://www.nature.com/articles/s41588-024-01990-6 6. https://www.nature.com/articles/s41588-024-01973-7 7. https://www.nature.com/articles/s41586-024-08216-z 8. https://www.nature.com/articles/s41586-024-08189-z 9. https://www.nature.com/articles/s41586-024-08172-8 10. https://www.cell.com/cell/fulltext/S0092-8674%2824%2901030-4 11. https://www.embopress.org/doi/full/10.1038/s44320-024-00064-3 12. https://www.nature.com/articles/s41587-024-02465-z 13. https://www.nature.com/articles/s41592-024-02501-5 14. https://www.nature.com/articles/s41592-024-02496-z

1. Tracking transcription–translation coupling in real time 2. An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung | Science 3. Identifying specific functional roles for senescence across cell types: Cell 4. Transcriptomic landscape of mammalian ventral pallidum at single-cell resolution | Science Advances 5. Integrated analysis of immunometabolic interactions in Down syndrome |…

1. Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases 2. Programming tissue-sensing T cells that deliver therapies to the brain

1. https://meetings.aps.org/Meeting/NEF24/Session/B03.2 2. https://www.science.org/doi/10.1126/science.adn9947 2.