[카테고리:] Weekly Paper Selections – WPS

Papers from other journals: 1. DNA language model GROVER learns sequence context in the human genome | Nature Machine Intelligence 2. Origin, structure, and composition of the spider major ampullate silk fiber revealed by genomics, proteomics, and single-cell and spatial transcriptomics | Science Advances 3. Tissue-aware interpretation of genetic variants advances the etiology of rare…

Science, Cell 1. Brain region–specific action of ketamine as a rapid antidepressant | Science 2. Massively parallel analysis of single-molecule dynamics on next-generation sequencing chips | Science 3. Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex | Science 4. Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes | Science 5. Genomic patterns in…

이번에는 8-10월 Nature 지에서 나온 논문들 중 관심이 가는 논문들. 1. Scalable watermarking for identifying large language model outputs | Nature 2. Machine-guided design of cell-type-targeting cis-regulatory elements | Nature 3. Parallel molecular data storage by printing epigenetic bits on DNA | Nature 4. Targeting immune–fibroblast cell communication in heart failure | Nature 5. Spatial…

두 달 정도 가까이 쉬었더니 볼 논문들이 너무나 많다. 따라서 이번엔 저널을 나눠서 정리했고, 이번 게시물에서는 Nature Genetics에서 8-10월에 나온 논문들 중 관심이 가는 논문들이다. 1. Obesity-dependent selection of driver mutations in cancer | Nature Genetics 2. Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries | Nature…

1. Genetic factors associated with reasons for clinical trial stoppage | Nature Genetics Clinical Trial failure and genetic factors 2. Gut microbiota carcinogen metabolism causes distal tissue tumours | Nature 3. AI models collapse when trained on recursively generated data | Nature 4. DNA language model GROVER learns sequence context in the human genome |…

1.The correlation between CpG methylation and gene expression is driven by sequence variants | Nature Genetics 2. Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression | Nature Genetics 3. Mitochondrial DNA mosaicism in normal human somatic cells | Nature Genetics 4. Next-generation phenotyping integrated in a national…

1. Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer | Nature Genetics 3D Genome , DNA + RNA + Epi, ecDNA 도 봄, AR gene/Prostate Cancer 2. Position-dependent function of human sequence-specific transcription factors | Nature TF function is position-dependent. 3. 2407.11734v1.pdf (arxiv.org)

1. Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import | Nature Genetics MR + Metabolite 2. Unsupervised representation learning on high-dimensional clinical data improves genomic discovery and prediction | Nature Genetics 3. Sources of gene expression variation in a globally diverse human cohort | Nature Pan-expression? eQTL? 4. In…

1. Saturation genome editing of BAP1 functionally classifies somatic and germline variants | Nature Genetics 2. Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosis | Nature Genetics 3. Semantic encoding during language comprehension at single-cell resolution | Nature Neural signal to language, 4. An atlas of transcribed enhancers across helper T cell diversity…

1. Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer | Science Dendritic cells and immunotherapy 2. Mef2d potentiates type-2 immune responses and allergic lung inflammation | Science 3. Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor | Science