[Target Discovery / Novel Target] 회사마다 핵심이 되는 Paper 모음

Insilico Medicine:
A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models | Nature Biotechnology

Exscientia:
문헌에서 타겟탐색
Serrano Najera et al 2021.pdf (prismic.io)

PheWAS+언어모델로 타겟 우선화
Narganes-Carlon et al Sci Rep 2023.pdf (prismic.io)

Recursion OS:
scRNA, image 로 데이터 모으기
Scientific Materials (recursion.com)

Owkin:
RCT에서 Subgroup 분석방법
Subgroup analysis methods for time-to-event outcomes in heterogeneous randomized controlled trials – Owkin

기업 레벨의 약물개발을 위한 연합학습
Industry-scale orchestrated federated learning for drug discovery – Owkin

Causaly:
타겟 안전성
Enhance Your Search Sensitivity with AI: Off-Target Effects of BRAF (causaly.com)
AI-Powered Drug Discovery: Identifying Safety Red Flags (causaly.com)

과학 문헌에서 더 정보를 잘 찾는 법
Eliminating Bias with Human-Centric AI (causaly.com)
Accelerate Target Discovery with the Help of AI (causaly.com)
Target Identification in Prostate Cancer (causaly.com)
Navigating the Biomedical Literature: Insights vs. Papers (causaly.com)

타겟 선호화
Exploring Biochemical Pathways with Human-Centric AI (causaly.com)
Target Identification and Prioritization: Ovarian Cancer (causaly.com)
Search by Target Class: Enzyme Targets for Celiac Disease (causaly.com)

DisGeNet:
Piñero et al., 2021; Piñero et al., 2019; Piñero et al., 2016; Piñero et al., 2015

OpenTarget:
Cancer target 선호화
A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization: Cancer Cell

GWAS를 이용한 TD
Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity | Scientific Data (nature.com)
open targets post-GWAS analysis pipeline | Bioinformatics | Oxford Academic (oup.com)

네트워크+GWAS
Network expansion of genetic associations defines a pleiotropy map of human cell biology | Nature Genetics

Open Target 플랫폼 논문
next-generation Open Targets Platform: reimagined, redesigned, rebuilt | Nucleic Acids Research | Oxford Academic (oup.com)
Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics | Nucleic Acids Research | Oxford Academic (oup.com)

GWAS CI 에서 타겟 선호화
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci | Nature Genetics

GWAS Fine-mapping 을 통한 TD
Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes. – Abstract – Europe PMC