[WPS] 2024.06 W4

1. Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology | Nature Genetics

Druggability?

2. Next-generation data filtering in the genomics era | Nature Reviews Genetics

3. Synthetic surrogates improve power for genome-wide association studies of partially missing phenotypes in population biobanks | Nature Genetics

Biobank imputation and enhancement

4. Detecting hallucinations in large language models using semantic entropy | Nature

LLM

5. Multiscale topology classifies cells in subcellular spatial transcriptomics | Nature

6. Human SARS-CoV-2 challenge uncovers local and systemic response dynamics | Nature

Immune cell annotation 이란 이런 것이다

7. AlphaFold2 structures guide prospective ligand discovery | Science

8. Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development: Cell

Perturb-seq + GRN

9. Integration mapping of cardiac fibroblast single-cell transcriptomes elucidates cellular principles of fibrosis in diverse pathologies | Science Advances

MI 이후 시기별로 CF(Cardiac Fibroblast) 만 모아서 시퀀싱을 했다!

10. In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss | Science Advances

11. Structure and dynamics of enterovirus genotype networks | Science Advances

Virus-infected cell genotype network

12. Molecular causality in the advent of foundation models | Molecular Systems Biology (embopress.org)

SaezLab, Molecular causality 에 대한 review